WILLIAMS - HEMATOLOGY 9TH ED

Williams Hematology 9th Edition

The world’s most highly regarded reference text on the mechanisms and clinical management of blood diseases – completely updated to reflect the latest breakthroughs and advancements

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. Extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice

A full-color presentation that includes 700 photographs (300 of which are new to this edition) and 475 illustrations 

Informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis

Begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology

CONTENTS:

Part 1. Clinical Evaluation of the Patient

1. Initial Approach to the Patient: History and Physical Examination

2. Examination of Blood Cells

3. Examination of The Marrow

4. Consultative Hematology

Part 2. The Organization of the Lymphohematopoietic Tissues

5. Structure of the Marrow and the Hematopoietic Microenvironment

6. The Organization and Structure of Lymphoid Tissues

Part 3. Epochal Hematology

7. Hematology of the Fetus and Newborn

8. Hematology during Pregnancy

9. Hematology in Older Persons

Part 4. Molecular and Cellular Hematology

10. Genetic Principles and Molecular Biology

11. Genomics

12. Epigenetics

13. Cytogenetic and Genetic Abnormalities

14. Metabolism of Hematological Neoplastic Cells

15. Apoptosis and Autophagy

16. Cell cycle regulation and hematological disorders

17. Signal transduction pathways

18. Hematopoietic stem cells, progenitors, and cytokines

19. The inflammatory response

20. Innate immunity

21. Adaptive immunity

Part 5. Therapeutic Principles

22. Pharmacology and toxicity of antineoplastic drugs

23. Hematopoietic stem cell transplantation

24. Treatment of infections in the immunocompromised host

25. Antithrombotic therapy

26. Immune cell therapy

27. Vaccine therapy

28. Therapeutic apheresis: indications, efficacy, and complications

29. Gene transfer for therapy

30. Regenerative Medicine: Multipotential cell therapy for tissue replacement

Part 6. The Erythrocyte

31. Structure and Composition of the Erythrocyte Absorb former 30 Composition of Erythrocyte.

32. Erythropoiesis

33. Erythrocytes turnover

34. Clinical manifestations and classification of erythrocyte disorders

35. Aplastic anemia

36. Pure red cell aplasia

37. Anemia of chronic disease

38. Erythropoietic effects of endocrine disorders

39. The congenital dyserythropoietic anemias

40. Paroxysmal nocturnal hemoglobinuria

41. Folate, cobalamin and megaloblastic anemias

42. Iron Metabolism

43. Iron deficiency and overload

44. Anemia resulting from other nutritional deficiencies

45. Anemia associated with marrow infiltration

46. Erythrocyte Membrane Disorders

47. Erythrocyte Enzyme Disorders

48. The thalassemias

49. Disorders of hemoglobin structure: sickle cell anemia and related abnormalities

50. Methemoglobinemia and other dyshemoglobinemias

51. Fragmentation hemolytic anemia

52. Erythrocyte disorders as a result of chemical and physical agents

53. Hemolytic anemia due to infections with microorganisms

54. Immune Hemolytic Anemia

55. Alloimmune hemolytic disease of the fetus and newborn

56. Hypersplenism and hyposplenism

57. Primary and Secondary Polycythemias

58. The porphyrias

59. Hereditary and acquired (polyclonal) sideroblastic anemias

Part 7. Neutrophils, Eosinophils, Basophils, and Mast Cells

60. Structure and composition of neutrophils, eosinophils, and basophils

Composition of neutrophils

Absorbed into chapter 60

61. Production, distribution, and fate of neutrophils

62. Eosinophils and their disorders

63. Basophils and mast cells, and their disorders

64. Classification and clinical manifestations of neutrophil disorders

65. Neutropenia and neutrophilia

66. Disorders of neutrophil function

Part 8. Monocytes and Macrophages

67. Structure, biochemistry, and function of monocytes and macrophages Biochemistry and function of monocytes and macrophages ABSORBED into Chap 67.

68. Production, distribution, and fate of monocytes and macrophages

69. Classification and clinical manifestations of disorders of monocytes and macrophages

70. Monocytosis and monocytopenia

71. Inflammatory and malignant histiocytosis

72. Gaucher Disease and Related Lysosomal Storage Diseases Part 9. Lymphocytes and Plasma Cells

73. Structure, composition, and biochemistry of lymphocytes and plasma cells Composition and biochemistry of lymphocytes and plasma cells ABSORBED into Chap 73.

74. Lymphopoiesis

75. Functions of B lymphocytes and plasma cells in immunoglobin production

76. Functions of T lymphocytes: T-cell receptors for antigen

77. Functions of natural killer cells

78. Classification and clinical manifestations of lymphocyte and plasma cell disorders

79. Lymphocytosis and lymphocytopenia

80. Immunodeficiency diseases

81. Hematological manifestations of acquired immunodeficiency syndrome (AIDS)

82. Mononucleosis syndromes

Part 10. Lymphocytes and Plasma Cells

83. Classification and clinical manifestations of the clonal myeloid disorders

84. Polycythemia vera

85. Essential thrombocythemia

86. Primary myelofibrosis

87. Myelodysplastic disorders (Clonal cytopenias and oligoblastic leukemia)

88. Acute Myelogenous Leukemia

89. Chronic Myelogenous Leukemia and Related Disorders

Part 11. Malignant Lymphoid Diseases

90. Classification of Malignant Lymphoid Disorders

91. Acute Lymphoblastic Leukemia

92. Chronic Lymphocytic Leukemia

93. Hairy Cell Leukemia

94. Large Granular Lymphocytic Leukemia

95. General Considerations for Lymphomas: Epidemiology,

Etiology, Heterogeneity, and Primary Extranodal Disease

96. Pathology of Lymphomas

97. Hodgkin Lymphoma

98. Diffuse Large B-Cell Lymphoma and Related Diseases

99. Follicular Lymphoma

100. Mantle Cell Lymphoma

101. Marginal Zone B-Cell Lymphomas

102. Burkitt Lymphoma

103. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome)

104. Mature T-Cell and Natural Killer Cell Lymphomas

105. Plasma Cell Neoplasms: General Considerations

106. Essential Monoclonal Gammopathy

107. Myeloma

108. Immunoglobulin Light-Chain Amyloidosis

109. Macroglobulinemia

110. Heavy-Chain Disease

Part 12. Hemostasis and Thrombosis

111. Megakaryopoiesis and Thrombopoiesis

112. Platelet Morphology, Biochemistry, and Function

113. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis

114. Control of Coagulation Reactions

115. Vascular Function in Hemostasis

116. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis

117. Thrombocytopenia

118. Heparin-Induced Thrombocytopenia

119. Reactive Thrombocytosis

120. Hereditary Qualitative Platelet Disorders

121. Acquired Qualitative Platelet Disorders

122. The Vascular Purpuras

123. Hemophilia A and Hemophilia B

124. Inherited Deficiencies of Coagulation Factors II, V,V+VIII, VII, X, XI, and XIII

125. Hereditary Fibrinogen Abnormalities

126. von Willebrand Disease

127. Antibody-Mediated Coagulation Factor Deficiencies

128. Hemostatic Alterations in Liver Disease and Liver Transplantation

129. Disseminated Intravascular Coagulation

130. Hereditary Thrombophilia

131. The Antiphospholipid Syndrome

132. Thrombotic Microangiopathies

133. Venous Thrombosis

134. Atherothrombosis: Disease Initiation, Progression, and Treatment

135. Fibrinolysis and Thrombolysis

Part 13. Transfusion Medicine

136. Erythrocyte Antigens and Antibodies

137. Human Leukocyte and Platelet Antigens

138. Blood Procurement and Red Cell Transfusion

139. Preservation and Clinical Use of Platelets

Index

Autores: Kenneth Kaushansky, Marshall Lichtman, Josef Prchal, Marcel M. Levi, Oliver Press, Linda Burns,

Michael Caligiuri

Editorial: Mc.Graw-Hill

Edición: 9ª

Año: 2016

Páginas: 2528

ISBN: 978-0-07-183301-1

Idioma: Inglés